Pediatric asthma control during the COVID‐19 pandemic: a systematic review and meta‐analysis – Yang – – Pediatric Pulmonology


With the onset of the COVID-19 pandemic, many experts expected asthma-related morbidity due to SARS-CoV-2 infection to increase dramatically. However, some studies suggested that there was no apparent increase in asthma-related morbidity in children with asthma, it is even possible that children have better outcomes. To understand the relationship between the COVID-19 pandemic and asthma outcomes, we conducted this article.


We searched PubMed, Embase, and Cochrane Library for literature from December 2019 to June 2021 related to Covid-19 and childhood asthma control, excluding results such as summaries, comments, letters, reviews, and case reports. The level of asthma control during the COVID-19 pandemic was synthesized and discussed by the outcomes of asthma exacerbation, emergency room visit, asthma admission, and c-ACT.


A total of 22159 subjects were included in 10 studies. Random effect model was used to account for the data. Compared to the same period before the COVID-19 pandemic, reduced asthma exacerbation (OR=0.26, 95%CI= [0.14,0.48], Z=4.32, P<0.0001), the probability of emergency room visits also decreased (OR =0.11, 95%CI= [0.04,0.26], Z=4.98, P<0.00001). The outcome of asthma admission showed no significant difference (OR =0.84, 95%CI= [0.32,2.20], Z=0.36, P=0.72). The outcome of c-ACT scores was not analyzed due to the different manifestations used. Overall, c-ACT scores declined during the pandemic.


Compared to the same period before the COVID-19 pandemic, the level of asthma control has improved significantly. We need to understand the exact factors that lead to these improvements and find ways to support them.

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